The Effects of Mitomycin C on Trabeculectomy. |
Soon Jae Hong, Sung Chur Moon, Kyung Won Yoo, Sae Heun Rho |
Department of Ophthalmology, College of Medicine, Dong A University, Pusan, Korea. |
섬유주절제술에 대한 Mitomycin C ( MMC ) 의 효과 |
홍순재(Soon Jae Hong),문성철(Sung Chur Moon),유경원(Kyung Won Yoo),노세현(Sae Heun Rho) |
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Abstract |
Mitomycin C (MMC) is an antimetabolite, antibiotic which prevents the proliferation of fibroblast and fibrosis by inhibition of DNA-dependent RNA synthesis. It has been used to increase the success rate of filtering surgery. We performed trabeculectomy and peripheral iridectomy with 0.4 mg/ml MMC application for 3 minutes in poor prognostic glaucoma patient, 26 eyes of 24 patients from February 1992 to December 1994. The postoperative change of intraocular pressure (IOP) and complications were followed up from 3 to 30 months (mean 12.4 months). The preoperative and postoperative mean IOP after 24 months were 32.3 +/- 11.4 mmHg and 12.7 +/- 3.1 mmHg, respectively. The decrease rate of IOP was 60.7% and the success rate was 71.7%. The postoperative complications were 15 eyes including 5 eyes of shallow anterior chamber, 5 eyes of hyphema, 2 eyes of conjunctival wound leakage, one eye of bleb rupture, one eye of choroidal detachment, and one eye of cataract formation. |
Key Words:
Intraocular pressure (IOP);Mitomycin C (MMC);Poor prognostic glaucoma;Trabeculectomy |
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