| Efficacy of Ciprofloxacin-soaked Collagen Shields for Treatment of Experimental Staphylococcus aureus Keratitis in Rabbits. |
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Yu Hwan Lee, Young Ho Hahn, Kwang Hyuk Kim |
1Department of Ophthalmology, Kosin Medical College, Pusan, Korea.
2Department of Microbiology, Kosin Medical College, Pusan, Korea. |
| 실험적 Staphylococcus aureus 각막염에서 Ciprofloxacin 을 적신 Collagen Shield의 치료효과 |
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이유환(Yu Hwan Lee),한영호(Young Ho Hahn),김광혁(Kwang Hyuk Kim) |
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| Abstract |
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In order to study the efficacy of a 0.2% ciprofloxacin-soaked collagen shield for the treatment of Staphylococcus aureus keratitis, an experimental study was performed on 40 eyes of 20 rabbits. Twenty hours after intrastromal injection with S. aureus, the rabbits were divided into four groups: Group 1(10 eyes) was treated with a 0.2% ciprofloxacin-soaked collagen shield with an additional instillation of 0.2% ciprofloxacin drops every 30 minutes for 4 hours; Group 2 (10 eyes) was treated with a 0.2% ciprofloxacin-soaked collagen shield for 4 hours; Group 3 (10 eyes) was treated with 0.2% ciprofloxacin drops every 30 minutes for 4 hours; Group 4 (10 eyes) received BSS every 30 minutes for 4 hours as a control. Bacterial killing was quantitated by culturing corneal homogenates and calculating the number of viable bacteria (colony-forming units) per cornea. Groups 1, 2, and 3 showed significantly reduced numbers of bacteria compared with the control (p<0.01). The order of efficacy in the treatment for S. aureus keratritis were groups 1, 2 and 3, respectively, but the statistical difference was not significant among groups 1, 2, and 3(p>0.05). These results suggested that a 0.2% ciprofloxacin-soaked collagen shield may be an effective and convenient mode of therapy for S. aureus keratitis. |
| Key Words:
0.2% ciprofloxacin;collagen shield;Staphylococcus aureus keratitis |
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