The Effect of Daunorubicin on Experimental Proliferative Vitreoretinopathy.

Lee, Jae Hyun; Kwak, Hyung Woo; Choi, Woo Jeong

Original Article

Journal of the Korean Ophthalmological Society 1996;37(10):1656-1662.
Published online October 1, 1996.

The Effect of Daunorubicin on Experimental Proliferative Vitreoretinopathy.

Jae Hyun Lee, Hyung Woo Kwak, Woo Jeong Choi

Department of Ophthalmology, Kyung Hee University, Seoul, Korea.

증식성 유리체 망막증에 대한 Daunorubicn 의 효과

이재현(Jae Hyun Lee),곽형우(Hyung Woo Kwak),최우정(Woo Jeong Choi)

Abstract

Proliferative vitreoretinopathy (PVR) is a main cause of failure in retinal reattachment surgery. There have been many studies about the inhibition of proliferative vitreoretinophthy with several drugs. Authors investigated the inhibitory effect of proliferative vitreoretinopathy and retinal toxicity with various concentration of daunorubicin after intravitreal injection into the eyes of the pigmented rabbit. 7 pigment rabbit (11eyes) were used as subjects. After lensectomy and vitrectomy, control group was injected dermal fibroblast and F-BSS, and treatment group was injected dermal fibroblast and 5, 10, 15, 30 nmol Daunorubicin. At two weeks after intravitreal injection, both group were enucleated and examined with gross finding, light--microscopy, and electronmicroscopy. In all control group, proliferative vitreoretinopathy was found, but only preretinal membrane formation was found in 5, 10 nmol Daunorubicin injected group. In 15 nmol Daunorubicin injected group, the retina structure was preserved normally. In 30 nmol Daunorubicin injected group, the retinal outer segment was degenerated in microscopic finding. These results show that Daunorubicin has a potent effect on proliferative vitreoretinopathy, especially in 15 nmol, but retinal toxicity is suspected in marethan 30 nmol.

Key Words: Proliferative vitreoretinopathy (PVR);Daunorubicin;Dermal fibroblast;Vitrectomy;Intravitreal injection