The Inhibitory Effects of 5-fluorouracil on Experimental Proliferative Vitreoretinopathy.

Kim, Kwang Soo; Park, Sung Youl; Oh, Joon Sup

Original Article

Journal of the Korean Ophthalmological Society 1993;34(1):53-60.
Published online January 1, 1993.

The Inhibitory Effects of 5-fluorouracil on Experimental Proliferative Vitreoretinopathy.

Kwang Soo Kim, Sung Youl Park, Joon Sup Oh

Department of Ophthalmology, Keimyung University School of Medicine, Taegu, Korea.

실험적 증식성 초자체망막증에 대한 5-Fluorouracil 의 억제효과

김광수(Kwang Soo Kim),박성렬(Sung Youl Park),오준섭(Joon Sup Oh)

Abstract

Proliferative vitreoretinopathy (PVR) is the main cause of failure in retinal reattachment surgery, Vitrectomy combined with pharmacologic therapy to inhibit proliferating and contracting epiretinal membranes appears to be a promismg approach in the management of PVR. We investigated the inhibitory effect of intravitreal 5-fluorouracil (5-FU) on experimental PVE induced by intravitreal injection of homologous dermal fibroblast in pigmented rabbits. At 6 weeks after intravitreal injection, Goup I (fibroblast only), Group II (early treatment with 1mg of 5-FU), and Group Ill (delayed treatment with 1mg of 5-FU) developed the retinal detachment in 85.7%, 33.3%, and 58.3% respectively. The rate of retinal detachment was lower in treatment groups than in non-treatment group, but there was a statistically significant difference only between non-treatment group (Group I) and early-treatment group (Group II) (p<0.05). In the group that only 5-FU was injected (Group IV), the retinas were preserved in normal clinically and pathologically. These results show that 5-FU may exert a significant anti proliferative effect on intraocular proliferative disorders including PVR especially if the drug is administered more earlier.

Key Words: Fibroblast;5- Fluorouracil;Proliferative vitreoretinopathy