The Topical Effects of Antibiotics and Aprotinin in Experimental Pseudomonas Ketaititis.

Hong, Nae Sun; Kim, Jae Chan; Shyn, Kyuog Hwan

Original Article

Journal of the Korean Ophthalmological Society 1993;34(3):181-187.
Published online March 1, 1993.

The Topical Effects of Antibiotics and Aprotinin in Experimental Pseudomonas Ketaititis.

Nae Sun Hong, Jae Chan Kim, Kyuog Hwan Shyn

Department of Ophthalmology, Chung Ang University Hospital, Korea.

실험적 녹농균성 각막염에 있어 항생제 및 Aprotinin 의 효과

김재찬(Jae Chan Kim),신경환(Kyung Hwan Shyn),홍래선(Nae Sun Hong)

Abstract

The effects of the topically applied antibiotics and Aprotinin were evaluated in the experimentally induced pseudomonas aeruginosa keratitis in rabbits. 40 albino rabbits were used for this study and were divided into 8 groups according to the treatment protocols as follows: Aprotinin 40u/ml, 1,OOOu/ml, 1O,000u/ml, antibiotics (Ciprofloxacin and Tobramycin), and antibiotics and Aprotinin combined-treated group. The drugs were instilled in the rabbits, cornea 6 times per day for 2 weeks. The clinical evaluation was performed using a hand-held slit lamp every day. For the histopathologic examination, we enucleated every samples at different time intervals and prepared specimens for light microscope. The results were Aprotinin-treated group showed progression of ulcer infiltrates regardless of its concentrations. There was a statistically significant difference between the antibiotics-treated group and the control group (p<0.05). However, the combination of Aprotinin and antibiotics were not able to gain statistical significance when compare with antibiotics alone (p>0.05). There was no clinical and histopathological differences in the rabbit cornea between ciprofloxacin and tobramycin treated group (p>0.05).

Key Words: Antibiotics;Aprotinin;Pseudomonas keratitis