The Effect of 0.1% Topical Bunazosin(R) on the lOP of Normal Subjeets.

Ahn, Hee Bae; Yoo, Kyung Won; Rho, Sae Heun

Original Article

Journal of the Korean Ophthalmological Society 1993;34(4):321-326.
Published online April 1, 1993.

The Effect of 0.1% Topical Bunazosin(R) on the lOP of Normal Subjeets.

Hee Bae Ahn, Kyung Won Yoo, Sae Heun Rho

Department of Ophthalmology, Dong-A University College of Medicine Busan, Korea.

정상인의 안압에 미치는 0.1% Bunazosin(R) 의 효과

안희배(Hee Bae Ahn),유경원(Kyung Won Yoo),노세현(Sae Heun Rho)

Abstract

The effects of topically applied bunazosin hydrochloride, Which has been developed as a highly selective alpha-1 adrenergic antagonist, on intraocular pressure(IOP), pupillary diameter, conjunctival injection, ptosis, and blood pressure were investigated in 14 normal volunteers. It is known that the mechanism of lOP reduction appears to be an increase in uveoscleral outflow and/or a decrease in episcleral venous pressure. The purpose of this experiment is to observe the effects of 0.1 % Bunazosin(R) on the lOP, pupil size, lid, conjunctival change and blood pressure in the normal human subject. The effects of 0.1% topical bunazosin(R) have been observed with placebo-controlled, double-blind single-dose study. The drug reduced lOP for 10 hours, and the decrease was statistically significant(p value <0.05). The lOP was decreased maximally at 3 hours after the instillation of the drug and the amount of the lOP reduction was 4.2mmHg. There were no significant changes of pupil size, lid configuration, conjunctival injection, and blood pressure in this experiment.

Key Words: alpha-1 antagonist;Bunazosin;lOP