A Case of VADS Induced by Immunosuppessants Therapy in Uveitis Patient.

Shin, Sung Gyun; Chung, Eui Hong; Yoon, III Han; Won, In Gun

Case Report

Journal of the Korean Ophthalmological Society 1993;34(5):474-479.
Published online May 1, 1993.

A Case of VADS Induced by Immunosuppessants Therapy in Uveitis Patient.

Sung Gyun Shin, Eui Hong Chung, III Han Yoon, In Gun Won

Department of Ophthalmology, College of Medicine, Inje University Pusan Baik Hospital, Pusan, Korea.

포도막염 환자에서의 면역 억제제 투여중 발생한 Virus Associated Hemophagocytic Syndrome ( VAHS ) 1 예

신성균(Sung Gyun Shin),정의홍(Eui Hong Chung),윤일한(Ill Han Yoon),원인건(In Gun Won)

Abstract

VAHS is characterized by viral-like prodromal symptoms, high fever' malaise, hepatosp lenomegaly, pancytopenia. The dignosis is based on a bone marrow biopsy specimen that demonstrates histiocytic hyperplasia with prominent hemophagocytosis of red blood cells, platelets, and nucleated hematopoietic cells Recently, the use of immunosuppressants tends to increase due to increase of autoimmune disease and organ transplantation patients. A large portion of leukemia and organ transplant patients developed VAHS as a secondary viral infection after anticancer drug and immunosuppressants therapy was administered In the field of ophthalmology, VAHS can occur by administration of immunosuppressants in corneal transplantation and autoimmune uveitis patients. Recently we experienced a case of fatal VAHS in a young uveitis patient who had been treated with immunosuppressants. We report this specfic case with literature review bec,lUse of the need for careful observation of general findings occurring during treatment of immunosuppressants such as corticosteroid.

Key Words: Immunosuppressants;Uveitis;VAHS