Effect of Vasomotor Drugs on the Choroidal Blood Flow in Rabbits.

Hong, Seung Ho; Youn, Won Shik

Original Article

Journal of the Korean Ophthalmological Society 1966;7(2):19-26.

Effect of Vasomotor Drugs on the Choroidal Blood Flow in Rabbits.

¹Department of Ophthalmology, School of Medicine, Seoul National University, Seoul, Korea.
²Department of Ophthalmology, Seoul Red Cross Hospital, Seoul, Korea.

혈관확장제 (血管擴張劑) 및 수축제가 (收縮劑) 맥락막혈류량에 (脈絡膜血流量) 미치는 영향 (影響)

윤원식(Won Sik Yoon),홍승호(Seung Ho Hong)

Abstract

The effect of intravenously administered vasoconstrictor (nor-epinephrine, ephedrine and posterior pituitary hormone) and vasodilator (papaverine, nicotinic acid and theophylline) drugs on the choroidal blood flow of rabbits was studied by the apparatus based on the principle of Grayson's internal calorimetry. Thermistors, as the sensing elements, were introduced into the suprachoroidal space of rabbits eye, and continuous determinations were performed up to 60 minutes after the administration. Papaverine(2mg/kg), theophylline (5mg/kg and 50mg/kg) and nicotinic acid (25mg/kg and 50mg/kg) produced significant increase in the blood flow, papaverine and theophylline being the most powerful. Among the vasoconstrictor drugs, posterior pituitary hormone produced profound and prolonged decrease in the blood flow, whereas nor-epinephrine and ephedrine increase the blood flow following transient decreases in the blood flow. The relationships between blood pressure, intraocular pressure and choroidal blood flow, and the suggestions in the therapeutic applications to human eye were discussed.