The Effects of Mitomycin C on Anterior Chamber Tube Shunt to a Surgical Membrane Surgery in Rabbits.

Choi, Woong San; Kim, Dong Myung

Original Article

Journal of the Korean Ophthalmological Society 1995;36(1):75-83.
Published online January 1, 1995.

The Effects of Mitomycin C on Anterior Chamber Tube Shunt to a Surgical Membrane Surgery in Rabbits.

¹Department of Ophthalmology, Dankook University, Hospital, Cheonan, Chungnam, Korea.
²Department of Ophthalmology, Seoul National University, Hospital, Seoul, Korea.

Silicone Tube 와 Expanded Polytetrafluoroethylene ( Surgical Membrane ) 을 이용한 가토의 녹내장 누공수술에서 Mitomycin C 의 효과

최웅산(Woong San Choi),김동명(Dong Myung Kim)

Abstract

To evaluate the effects of mitomycin C(MMC) on the fibrous capsule of the anterior chamber tube shunt to a surgical membrane(ACTSSM) surgery, 0.04% MMC solution was applied on the episclera for 5 minutes before ACTSSM surgery(group A, 9 rabbits). At postoperative 2, 4 and 8 weeks, 6 eyes of the 3 rabbits from each group were enucleated and light microscopic examinations of the fibrous capsules were done. In group A, fibrous capsules had many microcystic spaces and fibrous tissues between twofold surgical membranes were scanty. But in control group(group B, 9 rabbits), fibrous capsules showed higher density of fibroblast and less microcystic spaces than group A, suggesting low permeability of the fibrous capsule to aqueous humor. These results suggest that MMC may increase the success rate of the ACTSSM surgery.

Key Words: ACTSSM;Fibrous capsule;Mitomycin C