The Effects of Topical Cyclosporin A on Glaucoma Drainage Implant Surgery in Rabbits.

Park, Ki Ho; Kim, Dong Myung

Original Article

Journal of the Korean Ophthalmological Society 1995;36(2):307-315.
Published online February 1, 1995.

The Effects of Topical Cyclosporin A on Glaucoma Drainage Implant Surgery in Rabbits.

Ki Ho Park, Dong Myung Kim

Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.

가토에서 녹내장유출삽입물수술시 Cyclosporin A 의 국소 투여 효과

김동명(Dong Myung Kim),박기호(Ki Ho Park)

Abstract

To assess the effects of topical cyclosporin A(Csa) on the function of fibrous capsule and fibroblast proliferation after glaucoma drainage implant surgery in rabbits, we compared intraocular pressure(IOP), outflow resistance through the capsule and fibroblast density in capsule and fibroblast density in capsule among three groups: group A(12 eyes) that received implant surgery only, group B(11eyes) trated with topical 2% CsA twice a day for 2 weeks after implant surgery, and group C(14 eyes) with intraoperative subcon-junctival soaking of 2% CsA for S minutes and postoperative topical 2% CsA twice a day for 2 weeks. There was significant postoperative IOP decreases at 2, 4 and 8 weeks in group B(7.3 +/- 2.0. 7.1 +/- 1.7, and 6.6 +/- 1.8 mmHg, respectively) and group C(7.8 +/- 2.6, 7.1 +/- 1.7, and 6.8 +/- 1.6 mmHg, respectively) compared with group A(5.1 +/- 1.7, 5.0 +/- 1.0, and 4.8 +/- 1.5 mmHg, respectively)(p<0.01 for each). Flow resistances at postoperative 8 weeks were significantly lower in group Band group C than in group A(n=3. p<0.01). There was no significant difference in postoperative IOP decrease and outflow resistance between group B and Group C(p>0.05 for each). Fibroblast density was not significantly lower in group B and Group C than in group A(n=3, p=0.08). These results suggest adjunctive topical CsA may enhance the effectiveness of glaucoma drainage implant surgery.

Key Words: Cyclosporin A;Fibroblast;Glaucoma drainage implant surgery;Intraocular pressure;Outflow resistance