| Experimental Inhibitory, and Pharmacokinetic Stydy on The Development of Proliferative Vitreoretinopathy by Sustained Delivery of Intravitreal Fluoropyrimidenes. |
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Shin Dong Kim, Hyun Joo Kim, Ho Sung Yang, Dal Jun Jung, Kwang Hyuk Kim, Koo Il Kang, Noong Joo Lee, Hae Kon Kim |
1Department of Ophthalmology, School of Medicine, Kosin University, Korea.
2Department of Microbiology, School of Medicine, Kosin University, Korea.
3Department of Pharmacology, School of Medicine, Kosin University, Korea.
4Department of Premedical, School of Medicine, Kosin University, Korea.
5Dr. Kim's Eye Clinic, Korea. |
| 지속적 유리수단에 의한 Fluoropyrimidine 계 약물 초자체내 주사의 증식성초자체망막증 발생억제 효과와 약역동적 연구 |
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김신동(Shin Dong Kim),김현주(Hyun Joo Kim),양호성(Ho Sung Yang),정달전(Dal Jun Jung),김광혁(Kwang Hyuk Kim),강구일(Koo Il Kang),이능주(Noong Joo Lee),김해곤(Hae Kon Kim) |
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| Abstract |
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The efficacy of the sustained release-delivery system was tested in suppressing the development of proliferative vitreoretinopathy(PVR) with intravitreal Fluoropyrimidines(5-Fu: FU, Fluorouridine: FUD, 5-Fluoro-5'-monophosphate: FUMP). PVR was induced in one-hundred-eightyeight eyes of one-hundred-twenty rahbits by intravireal injection of homologous dermal fibroblasts(250.000 cells/0.1 ml). Each drugs were encapsulated with liposome(LFU. LFUD. LFUMP) or polymer(PFU. PFUD) and non-coated drugs wer e used as controls. 3 weeks after injections of fibroblasts, retina detached in 50.0% of control eyes. Among treated eyes, the detachment rates in percentage are as follows; FU 37.5, FUD 50.3, LFU 37.5, LFUD 37.5, PFU 16.7, PFUD 22.2. For the pharmacokinetic study. radiolaveled(-14C) drugs were used in liposome group and frozen vitreouses were measured by scintillatng counter; polymer group was measured by HPLC. The intravitreal half life(hour) of injected drugs were FU 3.2, FUMP 2.9, LFU 7.1, LFUMP 7.6, and PFU was exceptionally long(11.1 days). |
| Key Words:
5-fluorouracil;5-fluorouridine-5'-monophosphate;Proliferative Vitreoretinopathy;Liposome;Polymer |
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