A Study on Mitomycin C Induced Damage to the Iris and Ciliary Body of Cats.

Kim, Han Gyu; Kang, Tae Jung; Lee, Sung Kun; Bae, Ji Hong

Original Article

Journal of the Korean Ophthalmological Society 1995;36(3):486-491.
Published online March 1, 1995.

A Study on Mitomycin C Induced Damage to the Iris and Ciliary Body of Cats.

Han Gyu Kim, Tae Jung Kang, Sung Kun Lee, Ji Hong Bae

¹Department of Ophthalmology, College of Medicine, Gyeongsang National University, Korea.
²Department of Ophthalmology, Masan Armed Forces Hospital, Korea.

전방내 Mitomycin C 주입시 고양이 홍채와 모양체에 미치는 영향

김한규(Han Gyu Kim),강태중(Tae Jung Kang),배재홍(Ji Hong Bae),이승근(Sung Kun Lee)

Abstract

This study was performed to investigate the toxicity of mitomycin C(MMC) on the iris and ciliary body of the cat. After anesthesia, MMC in 0.1, 0.2, or 0.4 mg/ml concenration was injected intracamerally and the equal volume of balanced salt solution(BSS) was injected intracamerally to the contralateral eye as a control. There were no significant difference between 0.1 mg/ml of MMC and BBS injection except for the enlargement of endoplasmic reticulum and destruction of cristae of ciliary body 14 days after MMC injection. Iris vessel was congested and mitochondria of ciliary body was enlarged and cristae was disrupted 7 days after 0.4 mg/ml of MMC injection. There were infiltration of inflammatory cell on the iris and increased cellular damage at the nonpigmented epithelium of ciliary body 21 days after 0.4 mg/ml of MMC injection. These results suggest that the caution is necessary to prevent high concentration of MMC from getting into the anterior chamber at the time of glaucoma filtering surgery in human.

Key Words: Mitomycin C;Iris;Ciliary body;Mitochondria;Endoplasmic reticulum