Journal of the Korean Ophthalmological Society 1995;36(10):1682-1686.
Published online October 1, 1995.
The Quantitative Analysis of Autofluorescence in the Aging Crystalline Lens.
Seung Moo Ryu, Yong Il Park, Tae Hwa Oh, Won Ki Lee
Department of Ophthalmology, National Medical Center, Seoul, Korea.
연령에 따른 수정체 자가형광의 정량적 분석
류승무(Seung Moo Ryu),박용일(Yong Il Park),오태화(Tae Hwa Oh),이원기(Won Ki Lee)
Abstract
When illuminated by blue light, the human crystalline lens exhibits green autofluorescence. Autofluorescence of the human lens were analyzed quantitatively in vivo as a function of age in 75 healthy individuals{150 eyes) without cataract, ranging in age from 17 to 63 years. Lenses were scanned through the dilated pupil along the optical axis, generating a fluorescence profile consisting of anterior and posterior peaks of lens, using an automated scanning fluorophotometer(Fluorotron master) coupled with a lens system designed for high resolution of the anterior segment structures. Anterior peak autofluorescence increased linearly by 90 ng fluorescein/ml per decade and posterior peak autofluorescence by 70 ng fluorescein/ml per decade. No significant difference between right and left eyes was demonstrated for anterior or posterior peak autofluorescence. We suggest that the quantitative analysis of the autofluorescence of the human lens might be useful to investigate the changes of the aging lens proteins and the pathogenesis of cataract.
Key Words: Aging;Fluorophotometry;Lens autofluorescence


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