Treatment of Blepharospasm and Hemifacial apasm with Botulinum Toxin A(Oculinum(R))(I).

Koo, Hyun Nam; Kim, Jae Chan; Koo, Bon Sool

Original Article

Journal of the Korean Ophthalmological Society 1990;31(1):59-68.
Published online January 1, 1990.

Treatment of Blepharospasm and Hemifacial apasm with Botulinum Toxin A(Oculinum(R))(I).

Hyun Nam Koo, Jae Chan Kim, Bon Sool Koo

Department of Ophahtlmology, College of Medicine, Chung Ang Univereity, Seoul, Korea.

Botulinum Toxin A 에 의한 안검경련 및 반측안면경련의 치료 ( 1 )

김재찬(Jae Chan Kim),구본술(Bon Sool Koo),구현남(Hyun Nam Koo)

Abstract

Twenty cases of blepharospasm and thirty five cases of hemifacial spasm were treated by injection with Botulinum Toxin A during a fifteen-month period. A total of 74 treatment sessions were given for 7 months follow-up period and the mean dose of 17.81 units per lid and brow was administered according to Scott's method. The mean ages of blepharospasm and hemifacial spasm patients were 59 years and 49 years, respectively. The mean response time of toxin against blepharospasm and hemifacial spasm were 159.9 days and 167.1 days respectively. The maximum effect of toxin appeared in the first 1 month period following injection. The mean preinjection spasm grade was +3.17 in blepharospasm, and +2.41 in hemifacial spasm, and mean postinjection spasm grade was +0.88 in blepharospasm and +0.52 in hemifacial spasm. The mean preinjection muscle strength was +3.15 in blepharospasm, and +3.07 in hemifacial spasm, and mean postinjection muscle strength was +1.12 in blepharospasm, and +1.24 in hemifacial spasm. The complications attributed to toxin injection were lagophthalmos, and epiphora. These ocular complications were localized, mild and transient, and no systemic side effects were noted.

Key Words: Botulinum Toxin A;Eyelid spasm