Effect of Carteolol Hydrochloride on Sodium-Potassium Activated ATPase in Cattle Lena Epithelial Cell Membrane.

Lee, Ki Hoon; Chang, We Gon; Kang, Byung Nam

Original Article

Journal of the Korean Ophthalmological Society 1990;31(2):207-213.
Published online February 1, 1990.

Effect of Carteolol Hydrochloride on Sodium-Potassium Activated ATPase in Cattle Lena Epithelial Cell Membrane.

Ki Hoon Lee, We Gon Chang, Byung Nam Kang

Department of Ophthalmology, Seoul Red Cross Hospital, Seoul, Korea.

Carteolol hydrochloride 가 Na-K ATPase 의 활성도에 미치는 영향

이기훈(Ki Hoon Lee),장외곤(We Gon Chang),강병남(Byung Nam Kang)

Abstract

The effect of Carteolol hydrocholride on the Na-K ATPase of anterior capsule and epithelium of cattle lens has been investigated. The experiments were also designed to determine the action of Carteolol hydrochloride on the Na-K ATPase activity in anterior capsule and epithelium of cattle lens. The following results were observed. 1. The predominent location of Na-K ATPase was located in the epithelim and NaK ATPase was closely related with active trasport system of sodium and potassium in the lens epithelium. 2. The activity of Na-K ATPase of cattle lens epithelium was alomst totally inhibited by Ouabain. 3. Beta-adrenergic blocking agent(Carteolol hydrochloride) in the epithelium of cattle lens was shown to be actively transported by the ATPase. 4. The Na-K ATPase activity of cattle lens epithelium was inhibited by Carteolol hydrochloride.

Key Words: Active transport;Na-K ATPase;Inorganic phosphate;Carteolol hydrochloride;Cat aract formation