Experimental Intraocular Fibrovascular Proliferation Through Sclerommy Wound.

Lim, Jin Ock; Park, Kiho; Lee, Jaeheung

Original Article

Journal of the Korean Ophthalmological Society 1990;31(6):753-760.
Published online June 1, 1990.

Experimental Intraocular Fibrovascular Proliferation Through Sclerommy Wound.

Jin Ock Lim, Kiho Park, Jaeheung Lee

Department of Ophthalmolog, College of Medicine, Seoul National University, Korea.

공막창을 통한 안구내 조직 증식에 관한 연구

박기호(Ki Ho Park),임진옥(Jin Ock Lim),이재흥(Jae Heung Lee)

Abstract

In the process of closing a scleral wound caused by various conditions, incarceration af the conjunctiva, Tenon's capsule or vitreous in the wound can occur unexpectedly. We created such conditions experimentally to determine their intraocular complications. The experimental, materials were 12 albino rabhits(24 eyes) and the rabbits were divided into two groups(I and II). Group I rabbits(12 eyes) received no vinectormy and group II rabbits(12 eyes) received a vitrectormy. After the conjunctiva and Tenon's capsule flap was made, the tissue flap was inserted into the vitreous cavity through the sclerotomy site- Fundus examination with an indirect ophthalmoscope and enucleation for histology were performed at 3 days, 1 week, 3 weeks, 6 weeks, 3 months and 6 months after the experiment. The results were as follows: 1, Intraocular fibrovascular proliferation developed in all experimental rabbit eyes. 2. The more vitreous hemorrhage developed, the greater was the fibrovascular proliferation and the degree of fibrovascular proliferation was more marked in group II than group I. 3. The fibrovascular proliferation developed to a band in 3 weeks, then regressed gradually. 4. The fibrovascular band was composed of fibroblasts, stromal matrix and few vessels.

Key Words: fibroblagts;intraocular fibrovascular proliferation;sclemtomy;vineous hemorrhage