Effect of Epinephrine or Pilocarpine on me Ocular Blood Flow.

Lee, Kyoo Won

Original Article

Journal of the Korean Ophthalmological Society 1990;31(6):767-771.
Published online June 1, 1990.

Effect of Epinephrine or Pilocarpine on me Ocular Blood Flow.

Kyoo Won Lee

Department of Ophthalmology, College of Medicine, Yeungnarn University, Daegu, Korea.

녹내장 국소 점안제가 안혈류에 미치는 영향

이규원(Kyoo Won Lee)

Abstract

The ocular vascular resistance of the ciliary choroidal network has been investigated on measurements of pulse amplitude(PA). The ocular pulse is derived from the ciliary choroidal blood flow which account for more than 90% of the total ocular blood flow(OBF). In 5 normal Cynomolgus monkeys with topical application(50 micro l) of 2% epinephrine, the PA revealed a significant reduction(0.32 +/- 0.06mmHg, mean +/- SEM, p<0.01). In the other 5 normal Cynormlgus monkeys with 4% pilocarpine, the PA revealed no significant increment(0.32 +/- 0.15mmHg, mean +/- SEM, p<0.10) by the OBF system. These results suggest that topical application of epinephrine produces a significant reduction of OBR but pilocarpine produces a mild increment of OBF.

Key Words: Epinephrine;Ocular blood flow(OBF) Ocular pulse amplitude(PA);Ocular vas cular resistance;Pilocarpine