Inhibition of the Apraclonidine induced Reduction of Intraocular Presure by Topical Suprofen in Normal Human Eyes.

Kim, Chen Il; Kim, Hyo Myung; Jung, Hai Ryun

Original Article

Journal of the Korean Ophthalmological Society 1991;32(1):74-77.
Published online January 1, 1991.

Inhibition of the Apraclonidine induced Reduction of Intraocular Presure by Topical Suprofen in Normal Human Eyes.

Chen Il Kim, Hyo Myung Kim, Hai Ryun Jung

Department of Ophthalmology, College of Medicine, Korea University, Seoul, Korea.

정상안에서 1% Apraclonidine 과 Suprofen 병용시 안압 하강 억제 효과

김찬일(Chan Il Kim),김효명(Hyo Myung Kim),정해륜(Hai Ryun Jung)

Abstract

We studied the effect of prostaglandin synthesis inhibitor on the ocular hypotensive action of apraclonidine in a prospective, double-masked study. Twenty normal volunteers were studied. Suprofen, cyclooxygenase;nhibitor and apraclonidine were applied to one eye, and normal saline and apraclonidine to the other eye. Intraocular pressure(IOP) was then measured hourly in both eyes for 7 hours. The results showed significant reduction in mean IOP of both eyes one hour after apraclonidine application. The differences of IOP between the suprofen-treated eyes and control eyes were significant at 2 hours following treatment(p<0.05), reached maximum at 3 to 4 hours(p<0.01) and lasted until 7 hours(p<0.05). In suprofentreated eyes, there was less reduction of mean IOP than in control eyes. These results suggest that this reduction of IOP is at least in part mediated by prostaglandins or other cyclooxygenase products, since suprofen inhibits the ocular hypotensive effect of topically applied apraclonidine.

Key Words: Apraclonidine;Intraocular pressure;Suprofen