| Effect of Bovine Aqueous Humor on Prodution of IL-2 and IL-6, and Other Parameters of Immunoeompetency in Mice. |
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Daewoo Cha, Chunkyu Park, Taiyou Ha |
1Department of Ophthalmology, College of Medicine Chonbuck National University, Chonju, Korea.
2Department of Microbiology, College of Medicine Chonbuck National University, Chonju, Korea. |
| 우방수 (牛房水)가 마우스의 IL-2 및 IL-6 생산과 기타 면역반응에 미치는 영향 |
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차대우(Dae Woo Cha),박천규(Chun Kyu Park),하대유(Tai You Ha) |
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| Abstract |
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The injection of antigen into the anterior chamber of the eye results in a unusual pattern of systemic immune responses termed anterior chamber associated immune deviation(ACAID). This study was done to investigate the in vitro effect of bovine aqueous humor(BAR) on the proliferation response of murine spleen and thymus to mitogens, to determine in vivo effects of BAR on delayed-type hypersensitivity and hemagglutinin response to sheep red blood cells, and to examine contact hypersensitivity to dinitrofluorobenzene(DNFB). Also, the effect on in vivo exposure to BAH on the production of IL-2 and IL-6 of murine lymphocyte was investigated. As a result, various concentration of BAR inhibited or enhanced the proliferation response of mouse splenocytes to mitogens. BAR injection significantly enhanced 'Arthus reaction to SRBC, but failed to change DTR reaction to SRBC. Interestingly, however, BAR profoundly inhibited contact hypersensitivity to DNFB and HA response. BAR inhibited both IL-2 and IL-6 production of murine spleen and thymus cells. Taken together, these results suggest that BAR contains soluble factor(s) that can suppress or enhance immune response, depending on experimental conditions and that immunomodulatory activity of BAR is not species-specific. |
| Key Words:
Bovine aqueous humor;Interleukin-2 and 6 |
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