Morphological Changes of Retinal Pigment Epithelium After Experimental Retinal Detachment.

Han, Young Bock

Original Article

Journal of the Korean Ophthalmological Society 1992;33(2):159-165.
Published online February 1, 1992.

Morphological Changes of Retinal Pigment Epithelium After Experimental Retinal Detachment.

Young Bock Han

Department of Ophthalmology, College of Medicine, Ewha Woman's University, Korea.

실험적 망막박리후 망막색소상피세포에 나타나는 미세구조의 변화

한영복(Young Bock Han)

Abstract

After the rhegmatogenous retinal detachment was induced experimentally in the rabbit eyes, ultrastructural changes in the retinal pigment epithelium (RPE) were studied with electron microscope. After 3 days of retinal detachment, apical portion of the retinal pigment epithelium was mounded and apical processes were shortened, widened and reduced in number. In other areas proliferative changes were observed in the RPE and some of the proliferated cells migrated into the vitreal space. These changes were more progressed with time. Three weeks after retinal detachment, there were areas of fibroblast-like cells proliferation with production of collagen fibers. From the evidence of cell junctions, melanin granules in the Cytoplasm and basement membrane formation, proliferated fibroblast-like cells were thought to be originated from the RPE cells.

Key Words: Retinal detachment;RPE;Fibrocyte-like cells;Collagen fiber