Clinical and Pathelogic Findings in Retinoblastoma.

Pak, Byung Guk; Oum, Boo Sup

Original Article

Journal of the Korean Ophthalmological Society 1976;17(4):397-404.
Published online April 1, 1976.

Clinical and Pathelogic Findings in Retinoblastoma.

Byung Guk Pak, Boo Sup Oum

Department of Ophthalmology, College of Medicine, Busan National University, Busan, Korea.

망막 모세포종의 임상적 및 병리학적 고찰

박병국 , 엄부섭 ( Byung Gook Park , Boo Sup Oum )

Abstract

Authors presented the clinical and histopathologic review of 15 cases of retinoblastoma tor last 5 years. Retinal vasculatures in the non-tumorous portion of the retina were observed in 2 cases of retinoblastomas with trypsin digestion and stained with Wilder's reticulin and PAS-Hematoxylin. The following results were obtained. 1. 12 of 15 cases of retinoblastomas were male. 2. 2/3 of the patients had their tumors diagnosed within 2 years, and same numbers of patients operated within 3 years of age. Unusually long period of evolution was noted. 3. Histopathologically, tumors showed necrosis, hemorrhages and calcications, and rosettes were found in 9 cases. The retinoblastoma without rosettes invaded the ocular structures more frequentIy. 4. It suggested to retinal vascular patterns be closely related to onset and degree of differentiation of tumor cells. The retinal vasculatures in the non-tumorous part of retina showed saccular dilatation of the larger vessels associated with pooly differentiated capillary network (polygonal shape) in case of undifferentiated retinoblastoma. Another retinal vasculatures showed fibrous appearence of larger vessels associated with rnicroaneurysmal dilatation of capillaries in case of well differentiated retinoblastoma.