Ocular Hypotensive Effect of Levobunolol Hydrochloride.

Hong, Chul; Hong, Young Jae; Jung, Hai Ryun; Kim, Jae Myung; Youn, Dong Ho

Original Article

Journal of the Korean Ophthalmological Society 1992;33(5):501-506.
Published online May 1, 1992.

Ocular Hypotensive Effect of Levobunolol Hydrochloride.

Chul Hong, Young Jae Hong, Hai Ryun Jung, Jae Myung Kim, Dong Ho Youn

¹Glaucoma Service, Dr Hong's Eye Clinic, Seoul, Korea.
²Department of Ophthalmology, Yonsei University, College of Medicine, Seoul, Korea.
³Department of Ophthalmology, Medical College, Korea University, Seoul. Korea.
⁴Department of Ophthalmology, Kyung Hee University, College of Medicine, Seoul, Korea.
⁵Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.

Levobunolol Hydrochloride 의 안압하강효과

홍철(Chul Hong),홍영재(Young Jae Hong),정해륜(Hai Ryun Jung),김재명(Jae Myung Kim),윤동호(Dong Ho Youn)

Abstract

To estimate the clinical efficacy of a newly developed beta1 and beta2 - adrenoreceptor antagonist, levobunolol hydrochloride (Betagan), fifty six patients (96 eyes) with various types of glaucoma were enrolled in this study and were treated twice a day with 0.5% Betagan. Intraocular pressure (lOP), visual acuity, pupil size and cup/disc ratio were measured before and after Betagan treatment, at week 1, 2, 4, 8 and 12. The patients were also examined to check the subjective or objective local adverse reactions. All the patients showed significant reduction of lOP throughout the observation period without significant change of visual acuity, pupil size and cup/disc ratio. Additive hypotensive effect of Betagan was also noted when it was added to pilocarpine. In some patients, however, stinging sensation with tearing, photophobia, or foreign body sensation and punctate corneal erosion were noted after Betagan treatment; those were mild and transient.

Key Words: Levobunolol hydrochloride;beta-blocker;Glaucoma;Intraocular pressure (lOP)