Simulation of Proliferative Vitreoretinopathy in Pigmented Rabbits.

Lee, Jae Sun; Lee, Jaeheung

Original Article

Journal of the Korean Ophthalmological Society 1987;28(6):1229-1238.
Published online June 1, 1987.

Simulation of Proliferative Vitreoretinopathy in Pigmented Rabbits.

Jae Sun Lee, Jaeheung Lee

Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.

유색토끼를 사용한 실험적 증식성 초자체망막증 유발

이재선(Jae Sun Lee),이재흥(Jae Heung Lee)

Abstract

Proliferative vitreoretinopathy(PVR) is the most common cause of failure in retinal reattachment surgery. We performed three different procedures in 20 pigmented rabbits to get a simple model to induce experimental PVR. Rabbits were assigned randomly to three groups(I, II and III). Group I rabbits(5 rabbits, 10 eyes) received normal saline into vitreous cavity, after iatrogenic retinal tear was made. In group n rabbits(8 rabbits, 8 eyes), suspension of retinal pigment epithelium(RPE) and choroid of left eye was transferred into vitreous cavity of right eye. In group III rabbits(7 rabbits, 7 eyes), suspension of RPE and choroid of left eye was transferred into vitreous cavity of right eye after iatrogenic retinal tear was made. We observed the fundus for 2 months with, indirect ophthalmoscope. Incidence of retinal detachment of group I was zero(0/10) , that of group II was 37.5%(3/8), and that of group III was 85.7%(6/7). Electron microscopic findings of vitreous strand of one eye of group n showed central melanocytic core, peripheral fibroblast, and intercellular collagen fibril. Electron microscopic finding of one eye of group III revealed subretinal membrane composed of suspected RPE and glial cell.