Experimental Aconitine Neuroretinopathy in Rabbit Eye.

Bae, Jae Ki; Bae, Jae Yong; Kwak, Jyung Sik; Kim, Sang Ha; Seouk, Kui Deock

Original Article

Journal of the Korean Ophthalmological Society 1988;29(2):337-345.
Published online February 1, 1988.

Experimental Aconitine Neuroretinopathy in Rabbit Eye.

Jae Ki Bae, Jae Yong Bae, Jyung Sik Kwak, Sang Ha Kim, Kui Deock Seouk

¹Department of Ophthalmology, School of Medicine, Kyungpook University, Taegu, Korea.
²Department of Anatomical Pathology, School of Medicine, Kyungpook University, Taegu, Korea.
³Department of Biochemistry, College of Pharmacy, Hyosung Women's University, Taegu, Korea.

실험적 아코니틴 신경망막병증

배재기(Jae Ki Bae),배재용(Jae Yong Bae),곽정식(Jyung Sik Kwak),김상하(Sang Ha Kim),석귀덕(Kui Doeck Seouk)

Abstract

Toxic effects of Aconiti tuber, an important ingredient of Chinese medicinal preparation, have been encountered clinically. The chief bioactive and toxic constituent is the alkaloid aconitine. In this study histopathologic changes in the fine structures of rabbit eye by intravenously administered aconitine were examined with light and electron microscopes. The initial and most characteristic features observed in the histopathologic study were degenerative changes in the myelinated nerve fiber layer. So the effects of aconitine on the rabbit eye were primarily regarded as toxic neuropathy.