Effect of 5-Fluorouracil and Methotrexate on the Glaucoma Filtering Surgery.

Kim, Hai Gon; Yoon, Ill Han; Rho, Sae Heun

Original Article

Journal of the Korean Ophthalmological Society 1988;29(3):347-351.
Published online March 1, 1988.

Effect of 5-Fluorouracil and Methotrexate on the Glaucoma Filtering Surgery.

Hai Gon Kim, Ill Han Yoon, Sae Heun Rho

Department of Ophthalmology, Paik Hospital, Inje College, Pusan, Korea.

가토안에서 5 - Fluorouracil 과 Methotrexate 가 녹내장 여과 수술에 미치는 영향

김해곤(Hai Gon Kim),윤일한(Ill Han Yoon),노세현(Sae Heun Rho)

Abstract

The purpose of glaucoma filtering surgery is to maintain low intraocular pressure that do not damage to the optic nerve. The failure of filtering surgery commonly result from scarring process at filtering site. 5-Fluorouracil and methotrexate are anti metabolites capable of inhibiting fibroblast proliferation. We aim to evaluate the inhibitory effect of the 5-fluorouracil and methotrexate subconjunctival injection into gelfoam, embeded suibconjunctivally over trabeculectomy site in the rabbit. In our experimental study, we observed that 5-fluorouracil and methotrexate inhibit the fibroblast proliferation in filtering site by light microscope. So, we report this result with a brief review of literatures.