A Case of Wegener's Granulomatosis with Ocular Involvement.

Kim, In Sik; Kim, Jae Chan; Shyn, Kyung Whan; Koo, Bon Sool

Case Report

Journal of the Korean Ophthalmological Society 1988;29(3):443-450.
Published online March 1, 1988.

A Case of Wegener's Granulomatosis with Ocular Involvement.

In Sik Kim, Jae Chan Kim, Kyung Whan Shyn, Bon Sool Koo

Department of Ophthalmology, College of Medicine, Chung Ang University, Seoul, Korea.

안증상을 동반한 Wegener 씨 육아종증 1 예

김인식(In Sik Kim),김재찬(Jae Chan Kim),신경환(Kyung Whan Shyn),구본술(Bon Sool Koo)

Abstract

Wegener's granulomatosis is characterized by necrotizing vasculitis and granuloma formation in both upper and lower respiratory tracts and in kidney. Other organs are also involved frequently. Ocular manifestations are Ehown in about 50% of patients with it. We experienced a case of Wegener's granulomatcsis developed prcgressive paranasal sinusitis and rhinitis combined with orbital and ocular involvement shown proptosis of both eyes, necrotic change of cornea and anterior portion of sclera in left eye and so forth. The diagnosis was confirmed by clinical findings and histopathologic features of tissue biopsy. The histopathology from periccular area of left eye had the typical findings of Wegener's granulomatosis with necrotizing vasculitis and granuloma formation. We had treated with oral cyclophosphamide(30~120mg/day) and corticosteroid(betamethaEcne 3mg 1M) and performed the enucleation of left eye due to widespread necrosis. The general condition and ocular findings were moderately improved with medical treatment but the eventual visual acuity was zero in right eye.