The Influence of Fluorescein Concentration on the Tear Film Break-Up Time(BUT).

Shim, Chang Bo; Nam, Moon Jin; Kim, Ki San; Oh, Joon Sup

Original Article

Journal of the Korean Ophthalmological Society 1989;30(1):23-27.
Published online January 1, 1989.

The Influence of Fluorescein Concentration on the Tear Film Break-Up Time(BUT).

Chang Bo Shim, Moon Jin Nam, Ki San Kim, Joon Sup Oh

Department of Ophthalmology, Keimyung University, School of Medicine, Daegu, Korea.

Tear Film Break - Up Time ( BUT ) 에 대한 Fluorescein 농도의 영향

심창보(Chang Bo Shim),남문진(Moon Jin Nam),김기산(Ki San Kim),오준섭(Joon Sup Oh)

Abstract

The Tear Film Break-Up Time(BUT) in the diagnosis of the dry eye syndrome was widely used, but its results were variable according to the methods of measuring BUTs. Especially, the method of Fluorescein administration and concentration had a great influence on BUT. The purpose of this study was to standardize the method used in measurement of BUT, particularly fluorescein solution concentration. We measured BUT in seven groups of different fluorescein solution concentration and total subjects were 464 persons. The results were as follows; 1. The mean BUT was 14.24 +/- 2.04 seconds in 0.12% Fluorescein solution, 11.73 +/- 2.11 seconds in 0.25% solution, 11.34 +/- 3.00 seconds in 0.5% solution, 10.3 +/- 3.50 seconds in 1% solution, 9.59 +/- 2.74 seconds in 2% solution, 7.56 +/- 1.84 seconds in 5% solution and 5.55 +/- 1.20 seconds in 8% solution. 2. The more Fluorescein concentration was, the shorter BUT became and there were statistically significant decrease in 0.25%, 0.5% and 2% Fluorescein solution.

Key Words: BUT;Fluorescein solution concentration