| Topical Autologous Fibronectin in the Treatment of Persistent Corneal Epithelial defects. |
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Ki San Kim, Moon Jin Nam, Joon Sup Oh, Rang Woon Park, In San Kim, Joon Seung Jo |
1Department of Ophthalmology, Keimyung University, School of Medicine, Korea.
2Department of Biochemistry, Kyungpook University, School of Medicine, Daegu, Korea. |
| 지속성 각막상피결손 환자에서 autologous fibronectin 국소점안의 효과 |
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남문진(Moon Jin Nam),김기산(Ki San Kim),오준섭(Joon Sup Oh),박낭운(Rang Woon Park),김인산(In San Kim),조준승(Joon Seung Jo) |
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| Abstract |
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Fibronectin, a glycoprotein, is present in plasma and extracellular matrix and is responsible for cellular adhesion. Fibronectin was purified from autologous plasma of two persistent corneal epithelial defect patients by affinity chromatogaphy and administered topically 500 micro ml, 2 dropsper time, five times a day for 3 weeks. Reepithelization began three to seven days after initiation of treatment with autologous purified fibronectin eyedrops, and epithelial defects healed nearly completely and subjective symptoms were relieved. No side effects were observed. Over a follow-up period of 4 to 23 wks, no recurrences were noted. |
| Key Words:
fibronectin;persistent corneal epithelial defect |
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