Experimental Vitreous Hemorrhage.

Lee, Jae Heung

Original Article

Journal of the Korean Ophthalmological Society 1977;18(4):323-326.
Published online April 1, 1977.

Experimental Vitreous Hemorrhage.

Jae Heung Lee

Department of Ophthalmology, Seoul National University, Seoul, Korea.

초자체출혈의 심험적 연구 Ⅰ. 토끼에서 초자체출혈의 유발과 hyaluronidase 의 영향

이재흥 ( Jae Heung Lee )

Abstract

Experimental vitreous hemorrhage was induced in rabbit eye by rupturing the choroidal vessels mechanically with a 26 gauge needle introduced into the eye through the supero-nasal quadrant of the sclera, 10mm posterior to the limbus. Absorption of vitreous hemorrhage was evaluated by indirect ophthalmoscopy in the following groups and pathological specimens were obtained three months after vitreous hemorrhage. Group I: after vitreous hemorrhage, no additional management was done for control(4 eyes). Group II: vitreous gel was disrupted mechanically with 26 gauge needle to liquefy the vitreous(4 eyes). Group III: 1cc of vitreous waS replaced with the same amount of normal saline prior to vitreous hemorrhage (4 eyes). Group IV: 0.3cc of hyaluronidase (75 units) was injected into the posterior vitreous prior to vitreous hemorrhage (4 eyes). In groups I, II, and IV, vitreous hemorrhages were completely absorbed in 8 to 10 weeks. whereas absorption time was shortened in group m to 6 to 8 weeks. Pathological specimen revealed no infiltrations of inflammatory cells, but only glial proliferations.