J Korean Ophthalmol Soc > Volume 58(8); 2017 > Article
Journal of the Korean Ophthalmological Society 2017;58(8):968-973.
DOI: https://doi.org/10.3341/jkos.2017.58.8.968    Published online August 15, 2017.
The Correlation between Cognitive Function and Glaucoma.
Sunjin Hwang, Yong Un Shin, Min Ho Kang, Hee Yoon Cho, Mincheol Seong
Department of Ophthalmology, Guri Hospital, Hanyang University College of Medicine, Guri, Korea. goddns76@hanmail.net
인지 기능과 녹내장의 상관관계에 대한 연구
한양대학교 의과대학 구리병원 안과학교실
Correspondence:  Mincheol Seong,
Email: goddns76@hanmail.net
Received: 18 May 2017   • Revised: 21 June 2017   • Accepted: 24 July 2017
To compare mini-mental state examination (MMSE) score between glaucoma group and normal control group and to evaluate the correlation between MMSE score and spectral domain-optical coherence tomography (SD-OCT) values in both groups. METHODS: This prospective study includes thirty glaucoma patients (eleven primary open angle glaucoma and nineteen normal tension glaucoma) and thirty normal controls. Retinal nerve fiber layer (RNFL) and Ganglion cell-inner plexiform layer (GC-IPL) thickness were measured with SD-OCT, and the average values of both eyes were used. The cognitive function was evaluated with MMSE by a single examiner. RESULTS: The mean MMSE scores of glaucoma group and normal group were 26.07 ± 2.95, and 27.00 ± 1.68 respectively (p = 0.137). MMSE score of less than 24 only showed in glaucoma group. MMSE score and RNFL thickness showed statistically no signifance in correlation (R² = 0.236; p = 0.070), however, MMSE score and GC-IPL showed statistically significant correlation (R² = 0.256; p = 0.048). CONCLUSIONS: Glaucoma patients tend to show low cognitive function even though the correlation between glaucoma patient and low cognitive function was not statistically significant. Therefore, the aspect of cognitive depression should be concerned, when facing glaucoma patients.
Key Words: Cognitive function;Glaucoma;Mini-mental state examination (MMSE)

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