J Korean Ophthalmol Soc > Volume 58(9); 2017 > Article
Journal of the Korean Ophthalmological Society 2017;58(9):1066-1073.
DOI: https://doi.org/10.3341/jkos.2017.58.9.1066    Published online September 15, 2017.
Female Hormone Factors Associated with Age-related Macular Degeneration in Menopausal Korean Women: KNHANES V.
Seung Kook Baek, Young Hoon Lee
1Hwasun Country Public Health Center, Hwasun, Korea.
2Department of Ophthalmology, Konyang University College of Medicine, Daejeon, Korea. astrix001@gmail.com
폐경기 여성에서 나이관련황반변성과 여성 호르몬 요인과의 관계: 제5기 국민건강영양조사 자료
백승국1⋅이영훈2
화순군 보건소1, 건양대학교 의과대학 안과학교실2
Correspondence:  Young Hoon Lee,
Email: astrix001@gmail.com
Received: 13 July 2017   • Revised: 16 August 2017   • Accepted: 4 September 2017
Abstract
PURPOSE
To investigate whether endogenous and exogenous female hormone exposures were associated with risks for age-related macular degeneration (AMD) in postmenopausal women. METHODS: This study included 4,479 postmenopausal females aged 45 years and older who completed the Korea National Health and Nutrition Examination Survey (KNHANES) V. The participants were divided into 4 groups: subjects with AMD, subjects without AMD, subjects with early AMD, and subjects with late AMD. Variables associated with endogenous and exogenous female hormone exposures were analyzed. RESULTS: Among the 4,479 participants, 516 were found to have AMD and 3,963 were normal. There was no significant difference between the AMD and normal groups execpt for age in the risk analysis. Of the total 516 AMD participants, 488 had early AMD and 28 had late AMD. Women with AMD who had used oral contraceptives longer in the past had significantly higher odds of late AMD than early AMD (odds ratio [OR] = 1.013, 95% confidence interval [CI]: 1.002–1.024). Increasing number of children was also associated with decreased odds of late AMD (OR = 0.672, 95% CI: 0.506-0.893). CONCLUSIONS: These findings suggest that exposure to endogenous and exogenous female hormones may influence the risk of AMD progression.
Key Words: Age-related macular degeneration;Female hormones;KNHANES V


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