Factors Related to Refractory Macular Edema in Branch Retinal Vein Occlusion. |
Ji Hyun Park, Jung Min Park |
Department of Ophthalmology, Maryknoll Medical Center, Busan, Korea. pjm1438@hanmail.net |
망막분지정맥폐쇄에 동반된 황반부종에서 유리체강 내 베바시주맙 3회 주입 후 비순응 관련 요인 |
박지현ㆍ박정민 |
메리놀병원 안과 |
Correspondence:
Jung Min Park, Email: pjm1438@hanmail.net |
Received: 8 June 2017 • Revised: 13 November 2017 • Accepted: 30 November 2017 |
Abstract |
PURPOSE To evaluate the factors associated with refractory macular edema (ME) secondary to branch retinal vein occlusion (BRVO) after three times of intravitreal bevacizumab (IVB) injections. METHODS: Ninety eyes of Ninety patients, who were retrospectively reviewed, were treated with IVB of 1.25 mg (0.05 mL) for ME secondary to BRVO, repeated three times at 4-week intervals and then followed-up for at least 4 months after the IVB. The patients were classified as refractory if there was an increase in the mean retinal thickness >150 µm when measured 1 month after the three injections. The patients were divided into two groups: a responsive group (46 eyes) and a refractory group (44 eyes). RESULTS: In univariate logistic regression analyses, age, diabetes mellitus, hypertension, visual acuity, maximal combined response b wave amplitude (Max B amp), maximal combined response B/A ratio (Max B/A), cone response b wave amplitude, subfoveal choroidal thickness (SFCT), and the number of hyperreflective foci (HF) were risk factors for refractory ME of BRVO (p = 0.045, p = 0.010, p = 0.037, p = 0.034, p = 0.003, p = 0.004, p = 0.001, p = 0.001 and p = 0.001, respectively). In backward multivariate logistic regression analyses, age, Max B amp, Max B/A, SFCT and number of HF were risk factors for refractory ME of BRVO (p = 0.024, p = 0.004, p = 0.047, p = 0.033 and p = 0.049, respectively). CONCLUSIONS: Baseline age, Max B amp, Max B/A, SFCT and number of HF predicted the probability of refractory ME secondary to BRVO after IVB. |
Key Words:
Bevacizumab;Branch retinal vein occlusion;Electroretinogram;Hyperreflective foci;Subfoveal choroidal thickness |
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