J Korean Ophthalmol Soc > Volume 58(12); 2017 > Article
Journal of the Korean Ophthalmological Society 2017;58(12):1404-1409.
DOI: https://doi.org/10.3341/jkos.2017.58.12.1404    Published online December 15, 2017.
Progression of Visual Field Loss and Body Mass Index in Normal Tension Glaucoma.
Ah Young Kim, Kyung Eun Han, Roo Min Jun, Kyu Ryong Choi
The Institute of Ophthalmology and Optometry, Department of Ophthalmology, Ewha Womans University College of Medicine, Seoul, Korea. ckrey02@ewha.ac.kr
정상안압녹내장에서 시야손상 진행과 체질량지수
김아영⋅한경은⋅전루민⋅최규룡
이화여자대학교 의학전문대학원 안과학교실 이화 시과학연구센터
Correspondence:  Kyu Ryong Choi,
Email: ckrey02@ewha.ac.kr
Received: 24 August 2017   • Revised: 13 October 2017   • Accepted: 24 November 2017
Abstract
PURPOSE
To evaluate the association between body mass index (BMI) and visual field (VF) progression in normal tension glaucoma (NTG) patients. METHODS: We reviewed the medical records of 78 eyes of 78 NTG patients who were treated with eye drops for more than 18 months. Age, sex, existence of hypertension (HTN), diabetes mellitus (DM), refractive error, baseline intraocular pressure (IOP), IOP reduction ratio, baseline VF indices including mean deviation (MD) and pattern standard deviation, VF progression rate (MD slope, dB/year), number of eye drops, and BMI were analyzed. The progression of VF was determined by glaucoma change probability analyses (STATPAC 2) using a Humphrey field analyzer. RESULTS: The mean follow-up in consecutive eyes was 4.4 ± 2.7 years. A total of 18 eyes showed progression and 60 eyes did not. The VF progression rate (p < 0.001) and number of eye drops (p = 0.024) showed statistical differences, but age, sex, existence of HTN and DM, refractive error, baseline IOP, IOP reduction ratio, baseline VF index, and BMI did not show a statistical difference between the two groups (all, p > 0.05). However, multiple linear regression analyses showed that a lower BMI was significantly associated with faster VF progression in the progression group (β = 0.078; standard error = 0.030; p = 0.027). CONCLUSIONS: In the group in which VF loss progressed despite treatment with eye drops, a lower BMI was associated with progression of VF loss in NTG patients.
Key Words: Body mass index;Normal tension glaucoma;Obesity;Visual field progression


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