J Korean Ophthalmol Soc > Volume 59(2); 2018 > Article
Journal of the Korean Ophthalmological Society 2018;59(2):117-122.
DOI: https://doi.org/10.3341/jkos.2018.59.2.117    Published online February 15, 2018.
Comparison of Osmolarity of Various Artificial Tears Products Commercially Available in South Korea.
In Ho Woo, Jun Gi Hong, Jung Ah Huh, Youngsub Eom, Hyo Myung Kim, Jong Suk Song
1Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea. crisim@korea.ac.kr
2Department of Ophthalmology, Daegu Fatima Hospital, Daegu, Korea.
국내 상품화된 다양한 인공눈물 제품의 오스몰 농도 비교
우인호1⋅홍준기2⋅허정아1⋅엄영섭1⋅김효명1⋅송종석1
고려대학교 의과대학 안과학교실1, 대구파티마병원 안과학교실2
Correspondence:  Jong Suk Song,
Email: crisim@korea.ac.kr
Received: 10 August 2017   • Revised: 21 September 2017   • Accepted: 20 October 2017
Abstract
PURPOSE
To compare the osmolarity of various artificial tear products commercially available in the Republic of Korea. METHODS: The osmolarity of the artificial tears was analyzed using TearLab® and Multi-Osmette™. We divided the artificial tear products into five groups, including hypo-osmolar 0.18% sodium hyaluronate (HA), iso-osmolar 0.1%, 0.15%, 0.3% HA, and 0.5% carboxymethylcellulose sodium (CMC), and measured three products per group. RESULTS: Among the 12 products of iso-osmolar artificial tears, there were seven products (58.3%) < 300 mOsm/L, and among the three products of hypo-osmolar artificial tears, there were two products (66.6%) < 150 mOsm/L. A significant difference (p < 0.05) was observed between the iso-osmolar 0.3% HA group and the hypo-osmolar 0.18% HA group. In the iso-osmolar 0.1% HA and 0.15% HA, the difference between the products in each group was approximately 12 mOsm/L, and the CMC group had the smallest deviation among products, which was close to 300 mOsm/L. There was a significant difference of 305.57 ± 6.38 mOsm/L in the iso-osmolar 0.15% HA group, 293.44 ± 8.71 mOsm/L in the 0.1% HA group, and 285.67 ± 3.67 mOsm/L in the 0.3% HA group (p < 0.001). There was no significant difference in osmolarity between the iso-osmolar products containing HA and CMC (p = 0.117). CONCLUSIONS: There was a difference in osmolarity between the published and actual measured values of commercial artificial tears, and there was a difference in osmolality depending on the content of HA and the manufacturer.
Key Words: Artificial tears;Dry eye;Osmolarity;TearLab®


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