| Long-term Treatment Outcome of Intravitreal Aflibercept Monotherapy for Polypoidal Choroidal Vasculopathy. |
|
Ye Ji Kim, Sang Yun Han, Jong Woo Kim, Chul Gu Kim, Dong Won Lee, Jae Hui Kim |
|
Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, Korea. kjh7997@daum.net |
| 결절맥락막혈관병증에서 유리체강 내 애플리버셉트 단독치료의 장기 결과 |
|
김예지⋅한상윤⋅김종우⋅김철구⋅이동원⋅김재휘 |
|
건양대학교 의과대학 김안과병원 안과학교실 |
Correspondence:
Jae Hui Kim,
Email: kjh7997@daum.net
|
|
Received: 14 December 2017 • Revised: 3 January 2018 • Accepted: 19 February 2018 |
| Abstract |
PURPOSE
To evaluate long-term treatment outcomes of intravitreal aflibercept monotherapy for polypoidal choroidal vasculopathy (PCV). METHODS: A retrospective review of medical records was performed with 46 patients who were diagnosed with PCV and treated with aflibercept monotherapy for 24 months. Best-corrected visual acuity (BCVA) values measured at diagnosis, 3 months, 12 months, and 24 months were compared. Baseline morphological factors associated with the 24 month BCVA were additionally investigated. RESULTS: The mean age of the patients was 65.8 ± 7.9 years. The patients were treated with a mean of 7.0 ± 2.3 aflibercept injections. The mean logarithm of the minimal angle of resolution (logMAR) BCVA at diagnosis, 3 months, 12 months, and 24 months was 0.56 ± 0.40, 0.36 ± 0.36, 0.45 ± 0.42, and 0.52 ± 0.47, respectively. When compared with baseline values, the BCVA was significantly improved at 3 months (p < 0.001) and 12 months (p = 0.022). However, the value at 24 months was not significantly different (p = 1.000). The BCVA was improved or maintained in 35 eyes (76.1%). Extrafoveal polypoidal lesions were associated with a better 24 month visual outcome than subfoveal/juxtafoveal lesions. CONCLUSIONS: Aflibercept monotherapy was found to be an effective method to maintain or improve long-term visual acuity in PCV patients. The location of polypoidal lesions was a predictive factor for long-term visual outcomes. |
| Key Words:
Aflibercept;Age-related macular degeneration;Choroidal neovascularization;Long-term;Polypoidal choroidal vasculopathy |
|
PDF Links
Full text via DOI
Download Citation
