The Effect of Corneal Biomechanical Factors on Ocular Pulse Amplitude in Normal Subjects. |
Han Jo Kwon, Ji Woong Lee, Jong Hun Shin |
Department of Ophthalmology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea. jjongggal@naver.com |
정상인에서 각막 생체역학인자가 파스칼안압계를 이용한 안구박동크기에 미치는 영향 |
권한조⋅이지웅⋅신종훈 |
부산대학교 의학전문대학원 부산대학교병원 안과학교실 |
Received: 9 January 2015 • Revised: 19 February 2015 • Accepted: 19 June 2015 |
Abstract |
PURPOSE To investigate the influence of corneal biomechanical factors on ocular pulse amplitude measured using dynamic contour tonometry in normal subjects. METHODS: The study population consisted of normal subjects who visited the outpatient clinic from January, 2014 to July, 2014. Ocular pulse amplitude was measured using dynamic contour tonometry and corneal hysteresis (CH) and corneal resistance factor (CRF) were measured using an ocular response analyzer. We applied univariate and multivariate linear regressions to investigate the relationship between ocular pulse amplitude and corneal biomechanical factors and other ocular factors. RESULTS: Fifty eyes of 50 patients (average age 52.8 +/- 17.2 years) were examined. The average ocular pulse amplitude was 2.90 +/- 1.04 mm Hg and the CH and CRF were 10.44 +/- 1.96 mm Hg and 11.03 +/- 2.21 mm Hg, respectively. In univariate linear regression, factors influencing ocular pulse amplitude were ocular pressure based on CRF (beta = 0.280, p = 0.049), Goldmann applanation tonometry (beta = 0.293, p = 0.039), and spherical equivalent (beta = 0.283, p = 0.047), while in multivariate linear regression the only factor influencing ocular pulse amplitude was CRF (beta = 0.686, p = 0.042). CONCLUSIONS: A positive correlation between ocular pulse amplitude reflecting ocular perfusion pressure and CRF reflecting corneal elasticity was observed. Correlations between the 2 factors will be an important aspect in future studies regarding the influences of corneal biomechanical factors on ocular perfusion pressure in glaucoma patients. |
Key Words:
Corneal biomechanical factors;Dynamic contour tonometry;Ocular pulse amplitude |
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