Effect of Sodium Hyaluronate and Cyclosporine A on Tear Film in Dry Eye Syndrome.

Chang, In Boem; Park, Jung Hyun; Kim, Moo Sang; Kim, Tai Jin

doi:2013.54.2.231

J Korean Ophthalmol Soc > Volume 54(2); 2013 > Article

Original Article

Journal of the Korean Ophthalmological Society 2013;54(2):231-236.
DOI: https://doi.org/10.3341/jkos.2013.54.2.231 Published online February 28, 2013.

Effect of Sodium Hyaluronate and Cyclosporine A on Tear Film in Dry Eye Syndrome.

In Boem Chang, Jung Hyun Park, Moo Sang Kim, Tai Jin Kim

Department of Ophthalmology, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea. lasiklove@hanmail.net

안구건조증에서 히알우론산 단독치료와 사이클로스포린 A의 병합치료가 눈물막에 미치는 효과

장인범⋅박정현⋅김무상⋅김태진

Department of Ophthalmology, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea

Abstract

PURPOSE
To evaluate the efficacy of topical 0.1% hyaluronate (HA) and 0.05% cyclosporine A on tear film parameters in dry eye syndrome patients. METHODS: Patients who were diagnosed with dry eye syndrome were treated with mbined with cyclosporine A (Group 2, 54 eyes). Ocular surface disease index (OSDI), tear film break-up time (BUT), Schirmer's test, and tear osmolarity were evaluated before treatment and at 1, 2, 3, and 6 months after treatment. RESULTS: OSDI was significantly improved at 2 months after treatment and Schirmer's test results significantly improved at 1 month after treatment in both groups. The BUT was significantly improved 3 months after treatment in Group 1 and at 1 month after treatment in Group 2. Tear osmolarity significantly improved at 1 month after treatment in both groups, but continuously improved up to 6 months after treatment only in Group 2. The BUT and Schirmer's test showed greater improvements in Group 2 than in Group 1. CONCLUSIONS: Combined treatment of topical 0.1% HA and 0.05% cyclosporine A may be more effective for improving dry eye syndrome.

Key Words: Cyclosporine;Dry eye syndrome;Restasis;Tear osmolarity