| The Effect of Topical Mitomycin C after Excisional Biopsy in Conjunctival-corneal Intraepithelial Neoplasia: Two cases. |
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Jung Han Kim, Hyun Sung Kang, In Chul Kim |
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Department of ophthalmology, Presbyterian Medical Center. pmcoph@hitel.net |
| 결막 - 각막 상피내 신생물에 대해 절제 생검과 국소적 Mitomycin C 을 이용한 치료 경험 2 예 |
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강현성(Hyun Sung Kang),김정한(Jung Han Kim),김인철(In Chul Kim) |
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| Abstract |
PURPOSE
To investigate the effect of topical Mitomycin C(MMC) as a medical adjunct to incompletely excised conjunctival-corneal intraepithelial neoplasia(CCIN) for removal of remaining neoplastic cells and prevention of recurrence. METHODS: The authors applied postoperative topical 0.02% MMC adjunctively on 2 eyes of 2 patients with incompletely excised and histopathologically confirmed conjunctival-corneal intraepithelial neoplasia(CCIN) for 2weeks and if the lesion is not regressed, topical MMC treatment with the same regimen was added. RESULTS: Remaining lesions were completely regressed and no recurrence has been found with follow up to 25 months and 26 months in each case. CONCLUSIONS: Topical MMC chemotherapy would be an effective treatment modality on incompletely excised conjunctival-corneal intraepithelial neoplasia(CCIN) for removal of remaining neoplatic cells and prevention of recurrence. |
| Key Words:
Conjunctival-corneal intraepithelial neoplasia(CCIN);Incomplete Excision;Topical mitomycin C |
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