Study on the Effectivity and Stability of the Fortified Ophthalmic Solutions.

Kim, Jai Bong; Jeong, Sang Ki; Park, Yeoung Geol; Ryu, Phil Youl

Original Article

Journal of the Korean Ophthalmological Society 1993;34(5):468-473.
Published online May 1, 1993.

Study on the Effectivity and Stability of the Fortified Ophthalmic Solutions.

Jai Bong Kim, Sang Ki Jeong, Yeoung Geol Park, Phil Youl Ryu

¹Department of Ophthalmology, Chonnan University Medical School, Korea.
²Department of Microbiology, Chonnan University Medical School, Korea.

강화된 안약의 유효성과 안정성에 대한 연구

김재봉(Jai Bong Kim),정상기(Sang Ki Jeong),박영걸(Yeoung Geol Park),류필열(Phil Youl Ryu)

Abstract

The questions concerning storage temperature and storage duration of the fortified ophthalmic antibiotic solutions are raised. The aim of the current study is to evaluate the influence of fortified ophthalmic antibiotic solutions on its biological and physical properties according to the storage temperature and duration as time goes by. We examined the changes of pH, absorbance spectra, and anti-microbial activity of cefradine(63mg/ml)and gentamicin sulfate(13.6mg/ml) over a four-week period. The results were as follows: There was no difference between the potency of fortified GM solutions stored at 4 degrees C and that at 24 degrees C for 4 weeks. The cefradine stored 24 degrees C exhibited significant changes in both its tJotency and stability after ithe seventh day of storage. The cefradine stored at 4 degrees C exhibited changes in Its absorbance spectra day by day and potency after 14th day.

Key Words: Anti-microbial activity;Duration;Fortified antibiotic solutions;Storage;Temperature