Histopathological Findings of Schnyder's Crystalline Corneal Dystrophy.

Kim, Jun Hyung; Myong, Yoon Won

Case Report

Journal of the Korean Ophthalmological Society 1995;36(8):1363-1369.
Published online August 1, 1995.

Histopathological Findings of Schnyder's Crystalline Corneal Dystrophy.

Jun Hyung Kim, Yoon Won Myong

Department of Ophthalmology, St. Mary's Hospital, Catholic University Medical College, Seoul, Korea.

Schnyder 씨 결정각막이영양증의 조직소견

김준형(Jun Hyung Kim),명윤원(Yoon Won Myong)

Abstract

Schnyder's crystalline corneal dystrophy is a hereditary disease of unknown etiology, and characterized by bilateral subepithelial corneal opacification with crystalline or diffuse deposits of cholesterol or other lipid. It is rare and has never been reported in Korea. The authors experienced a case of Schnyder's crystallin corneal dystrophy examined in a 36-year-old man who had bilateral corneal crystalline deposits since 15 years old and significant reduction in vision for two years. Light microscopic examination of patient's keratoplasty specimen showed lipid deposits in the superficial stroma, and electron microscopy disclosed multiple lipid vacuoles in basal epithelium, Bowman slayer, superficial stroma and keratocytes. In this report, we describe the histopathological findings of Schnyder's crystalline corneal dystrophy.

Key Words: Corneal opacity;Lipid deposits;Schnyder's crystalline dystrophy