Clinical Effect of Cyclosporine 0.05% Eye Drops in Dry Eye Syndrome Patients. |
Yong Soo Byun, Eun Jeong Jeon, Sung Kun Chung |
Department of Ophthalmology and Visual Science, St. Mary's Hospital, The College of Medicine, The Catholic University of Korea, Seoul, Korea. eyedoc@catholic.ac.kr |
안구건조증 환자에서 사이클로스포린 0.05% 점안액의 임상효과 |
변용수ㆍ전은정ㆍ정성근 |
Department of Ophthalmology and Visual Science, St. Mary’s Hospital, The College of Medicine, The Catholic University of Korea, Seoul, Korea |
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Abstract |
PURPOSE We conducted a study to evaluate the change of tear secretion and symptoms in the patients with dry eye syndrome after using Restasis(R) (Cyclosporine 0.05% ophthalmic emulsion, Allergan Inc., U.S.A.). METHODS: We randomly selected 39 patients from newly or previously diagnosed dry eye syndrome patients and administered Restasis(R) to them. We checked their clinical parameters and symptoms over a period of 3 months. The clinical parameters evaluated were type I and type II Schirmer tests and tear break-up time, and the symptoms of dry eye syndrome were classified into pain, itching, foreign body sensation, blurred vision, and photophobia using a scoring scale for symptoms of 0 to 5. The results were analyzed with a Mann-Whitney test (P-values <0.05 was considered statistically significant). RESULTS: For 26 of 39 patients (52 eyes) on whom all tests were carried out for 3 months, there was a significant improvement after 3 months in the type I Schirmer test, type II Schirmer test, and tear break-up time (P=0.012, 0.009, 0.001, respectively). Only 14 patients completed the questionnaire for scoring of symptoms. After using Restasis(R), foreign body sensation only improved (P=0.010). CONCLUSIONS: In our study, tear secretion was increased by Restasis(R), and a greater increase in tear secretion was seen in patients with systemic disease than in patients without systemic disease. Additional patients need to be evaluated and longer-term studies need to be performed to confirm our results. |
Key Words:
Cyclosporine;Dry eye syndrome;Restasis(R) |
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